The Main difference is that VIPRE Business has a management console to manage agents installed on workstations. The agents are managed by a management console through policies that you can configure to allow or deny certain changes to be made to VIPRE. On the other hand, VIPRE antivirus for home is a stand alone product where each individual computer is responsible for managing itself. However, the protection they offer is identical because they use the same definition files for scanning and real-time protection.